McEnroe replaced his brother John in charge of the US team
Patrick McEnroe is to step down as US Davis Cup captain later this month after 10 years in charge.
His final match as captain will be a vital play-off against Colombia which the US need to win to stay in the competition's top tier.
McEnroe, the younger brother of former Wimbledon champion John, led the United States to a Davis Cup title in 2007 - their first since 1995.
"It's with a heavy heart I'm resigning as Davis Cup captain," said McEnroe.
"But it's a decision I felt was best. Davis Cup is a significant time commitment and this decision will allow me to focus more energy on my family and to the US Tennis Association's player development programme."
McEnroe was hired two years ago to run the USTA's scheme to develop elite players and he also works as a TV analyst.
Four-time Grand Slam winner Jim Courier has already indicated he would be interested in taking over from him.
Mardy Fish, Sam Querrey, John Isner and Ryan Harrison will represent the United States against Colombia.