Oregon quarterback Dennis Dixon, a Heisman Trophy front-runner who has guided the Ducks to an 8-1 record and a No. 2 BCS ranking, twisted his left knee Thursday and left in the first quarter against host Arizona.
ESPN's Erin Andrews reported from the sideline that Dixon, a big threat on the ground who also rates fourth in the nation in passing, would not return, a big blow for a team averaging almost 43 points and 511 yards a game.
Dixon's left knee appeared to buckle as he tried to plant on an option carry with about five minutes to go in the quarter.
Dixon sprained the same knee against Arizona State on Nov. 3. He wore a brace Thursday night.
Dixon had a 39-yard touchdown run on the Ducks' first possession. He was 5-of-8 for 62 yards and threw an interception in the end zone.
Senior Brady Leaf replaced Dixon.
The Associated Press contributed to this report.
Source: ESPN.com
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