Adkins joined Scunthorpe as a physio in 1996
Scunthorpe United have confirmed they have given boss Nigel Adkins permission to talk to Southampton over the vacant manager's job at St Mary's.
Adkins and his assistant Andy Crosby have agreed terms with the Saints but the clubs have yet to agree a compensation package.
The 45-year-old took over at Glanford Park in 2006 following the departure of Brian Laws to Sheffield Wednesday.
Adkins will replace Alan Pardew, who was sacked from his role in August.
Pardew was appointed as Saints boss in July 2009 but was dismissed from his role just three games into the current season.
Southampton currently lie 18th in League One having started as favourites to win the league.
Adkins became caretaker manager at Scunthorpe in November 2006, having previously worked as physio at the club, and was appointed in the full-time position a month later.
He guided the Iron to promotion to the Championship in 2007 and again in 2009 following their relegation in 2008.