Holders Manchester United will continue their defence of the Carling Cup with a trip to West Ham in the quarter-finals.
In the tie of the round, second city rivals Birmingham and Aston Villa have been drawn to meet at St Andrew's.
Arsenal are bidding to win their first piece of silverware since 2005 and they welcome Wigan to the Emirates Stadium.
Championship side Ipswich, the only non-Premier League club remaining, are rewarded for their win over Northampton with a home tie against West Brom.
Arsenal v Wigan
Birmingham v Aston Villa
West Ham v Manchester United
Ipswich v West Brom
Ties to be played on the weeks commencing 29 November